Behavioral Neurosciences
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DongDong Li
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My research focuses on DA receptor initiated signaling cascades leading to behavioral plasticity. The overarching goal is to characterize the molecular biological mechanisms underlying the generation of appetitive behaviors in the rat. Currently I am focusing on elucidating the contribution of PKA, PKC, and CaMKII to changes in AMPA receptor trafficking and function observed after exposure to psychostimulant drugs.
 

Papers:

Loweth JA, Li D, Cortright JJ, Wilke G, Jeyifous O, Neve RL, Bayer KU, Vezina P. Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition. The Journal of Neuroscience 2013, 33: 1411-1416.

Li D, Herrera S, Bubula N, Nikitina E, Palmer AA, Hanck DA, Loweth JA, Vezina P. Casein kinase 1 enables accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. Journal of Neurochemistry 2011; 118: 237-247.

Bryant CD, Graham ME, Distler MG, Munoz MB, Li D, Vezina P, Sokoloff G, Palmer AA. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology 2009; 203:703-11.

Li D, Feng Z, Zhang W. The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson’s disease mice induced by MPTP. Progress of Anatomical Science 2002; 8:27-30.

Li D, Gál I, Vermes C, Alegre M-L, Chong ASF, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J. Cbl-b: One of the Key Molecules Tuning CD28- and CTLA-4-Mediated T Cell Costimulation, Cutting Edge. The Journal of Immunology 2004; 173: 7135-7139.

Brorson JR, Li D, Suzuki T. Selective heteromeric expression of AMPA receptors driven by flip/flop differences. Journal of Neuroscience 2004; 24:3461-3470.

Li D, Marks JD, Schumacker PT, Young RM, Brorson JR. Physiological hypoxia promotes survival of cultured cortical neurons. European Journal of Neuroscience 2005; 22:1319-1326.

Li D, Shao Z, Vanden Hoek TL, Brorson JR. Reperfusion accelerates acute neuronal death induced by simulated ischemia. Experimental Neurology 2007; 206:280-287.

Abstracts (last two years):

Li D, Bohanon K, Vezina P. Exposure to amphetamine produces long-lasting changes in αCaMKII coupling in the nucleus accumbens. Society for Neuroscience Abstracts 2012; 38: 667.01.

Rodvelt KR, Li D, Neugebauer NM, Forneris J, Bubula N, Vezina P. D1-D2 dopamine receptor heteromers, PKC activation and the expression of amphetamine-induced locomotor sensitization. Society for Neuroscience Abstracts 2012; 38: 667.05.

Vezina P, Li D, Cortright JJ, Wilke G, Jeyifous O, Neve RL, Bayer KU, Loweth JA. Persistent reversal of enhanced amphetamine intake by transient viral-mediated inhibition of CaMKIIα in the nucleus accumbens shell. Society for Neuroscience Abstracts 2012; 38: 667.04.

Li D, Bubula N, Herrera S, Loweth JA, Nikitina E, Hanck D, Vezina P. Effect of the casein kinase 1 epsilon inhibitor PF-670462 on amphetamine-induced signaling in the nucleus accumbens. Society for Neuroscience Abstracts 2010; 36: 576.10.

Vezina P, Herrera S, Bubula N, Campioni M, McGehee DS, Li D. Previous exposure to amphetamine alters AMPA receptor flip/flop variants in the nucleus accumbens. Society for Neuroscience Abstracts 2010; 36: 576.9.

 


UCMC The University of Chicago Medical Center
Department of Psychiatry & Behavioral Neurosciences
5841 S. Maryland Ave., MC 3077
Chicago, IL 60637-1470
 
Last Update: January 2013