|My research investigates the neurobiological mechanisms underlying the expression of amphetamine-induced sensitization. Currently, I am examining the contribution of D1-D2 dopamine receptor heteromers and their proposed signaling pathway (Gq-phospholipase C-inositol triphosphate-protein kinase C) in amphetamine-induced locomotor sensitization and intracellular signaling. I am developing experiments using viral-mediated gene transfer to investigate the role played by downstream components of this signaling pathway, including neurogranin and AMPA receptor subunits, in amphetamine-induced locomotor sensitization, enhanced amphetamine self-administration and reinstatement of amphetamine-seeking in sensitized rats. The overall goals of my research are to elucidate the mechanisms contributing to the behavioral manifestations of drug addiction, and to identify novel targets for the development of effective therapies.
Rodvelt KR, Li D, Neugebauer NM, Forneris J, Bubula N, Vezina P. D1-D2 dopamine receptor heteromers, PKC activation and the expression of amphetamine-induced locomotor sensitization. Society for Neuroscience Abstracts 2012; 38: 667.05.
Rodvelt KR, Li D, Vezina P. D1-D2 dopamine receptor heteromers contribute to the expression of amphetamine-induced locomotor sensitization. Society for Neuroscience Abstracts, 2011.